Patient is at higher risk from a COVID infection because of their factor V Leiden mutation and history of a deep vein blood clot. I still think about how close I felt to death. Your Good Health: mRNA vaccines safe for those with factor V On the other hand, critically ill patients with COVID-19 and low levels of factor V appear to be at increased risk for death from a coagulopathy that resembles disseminated intravascular coagulation (DIC), a devastating, often fatal abnormality in which blood clots form in small vessels throughout the body, leading to exhaustion of clotting factors and proteins that control coagulation, report Elizabeth M. Van Cott, MD, investigator in the department of pathology at Mass General and colleagues. I never ever want to find myself in an ICU again. All authors reported no conflicts of interest to disclose. COVID-19 Vaccines for People Who Are Moderately or Severely I looked at the math, and the risk of clotting from the vaccine is so much lower than the risk of clotting from COVID, it was the easiest health care decision I could make for myself in these crazy, scary times. I have had both Pfizer vaccines without any issues. Since I have the factor V mutation, I have chosen not to get a vaccine for COVID. This potential new condition has been called vaccine-induced prothrombotic immune thrombocytopenia (VIPIT). Van Cott and colleagues also found that the clinical decline toward DIC was foreshadowed by a measurable change in the shape, or waveform, of a plot charting light absorbance against the time it takes blood to coagulate. Get the latest news, explore events and connect with Mass General. Factor V Leiden - Diagnosis and treatment - Mayo Clinic Finally, its important to note that COVID-19 itself has been reported to lead to thrombocytopenia in up to 41% of positive patients, with the figure rising to up to 95% in those with severe disease. Blood leaves the brain by moving into the venous sinuses (blue) and draining into the jugular vein. Booster shots are an important part of protecting your health and stopping the spread of COVID-19. My son may suffer from lasting consequences from it as his case is much worse than mine. [CDATA[// >